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27 Oct 2020 by Ludwig Boltzmann


Joint Transnational project in cardiovascular research driven by Early Career Scientists in the frame of MedUniGraz and LBI LVR.

Project presentation Salven Crnkovic: IMPHLeXIONS: Inflammation and Metabolism in Pulmonary Hypertension are linked to skewed chromosome X inactivation

Pulmonary arterial hypertension is a rare, but progressive fatal disease of the pulmonary circulation affecting primarily females. The INPHLeXIONS project consortium will investigate the underlying molecular mechanisms that lead to observed gender bias in this disease. Research groups from Austria, Germany and Canada will apply newly developed technologies to characterize aberrant inactivation of X chromosome-linked genes involved in inflammatory and metabolic processes. Gained insights will be used to develop and validate novel therapeutic options for pulmonary arterial hypertension.

Project partner: Konda Babu Kurakula (Max-Planck-Institute for Heart and Lung Research, Germany) and Roxane Paulin (Universite Laval, Canada)