Research Unit: Immune cell interaction in chronic lung disease
Team Leigh Marsh
An aberrant immune response underlies the pathogenesis of multiple chronic lung and cardiovascular diseases, however, these changes are not restricted to single cells or pathways, but rather a complex interplay of multiple immune cells interacting with the host organ. To this end, we take a holistic view and analyse the immune system as a whole by integrating analyses on multiple levels and across disciplines. Our interdisciplinary translational approach includes comprehensive inflammatory cell profiling using advanced flow cytometry and 3D cell and tissue imaging as well as single-cell RNA sequencing analysis. These approaches are combined with traditional molecular techniques, pre-clinical models and clinical data, to give a truly interdisciplinary translational approach to unravel the interaction and interdependence of these immune cells and determine their contribution to disease pathogenesis.